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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c33d66e7d06cdf1a3d342df63eb5dce727c55dbb83f71b377d7d778c42e4033' 
  AND token = 'mLSj/YtVwuqwWA3Gyfhn/SEYKbSrzOC4yZGzrHeKnkY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}