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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a241f498b7487156006aea92e27f30d3cba591bea45974395337324e08f337c5' 
  AND token = 'EzL3yTeRb3x9VXsaBhxo+C+t+DPdkFUtnLu0ZVIH7H0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}