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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b1b521ea6747c41c199403b5043a17b1dbb05e56b96789691deee114b3f3f042' 
  AND token = 'AatOp4PG5uEHWvs3XPVSuyMr+fyMf2HIyne0vWO7PCw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}