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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a8f33a62d826d0f3bafe0a6efb947a3bb9e7384912156e18c38c2b1829d1125' 
  AND token = 'f+NGIXFE4GMSbFuin80fqgz7FrvxFP22/bz1L1oeKY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}