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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '427d350e0688fa5718bf0a98e3be1b5adc4785b2241b87663f12553379f6bc2e' 
  AND token = 'aESkU0UrW1VqgZGJNTN3Gb8tVkfxx8UuKjeGia9KL3s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}