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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '503b8cd84ac6b9ef638e5098577f0574dfafedf3826b3d41f573208075a0409c' 
  AND token = '9kakexLyQx7NzbRQI251BmjNbiNuTMEoHhM1t0dh6UI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}