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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c33a4b48e48f04b4e1b7061fcd9344364a7c0aa1da2f9a603210fd06bb87504' 
  AND token = 'HxCwV5Kn7fKifdDf7cZYMCPh1p+l/+H5DR+bGYyM46E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}