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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64680016a1be013ff10efc490c7435c5aa735c172d0d73fb4c42f07c873f4431' 
  AND token = '+t1bx/Vf/JlO+ZhSxTC4N/4Sy1mKBrSQ9itBC4IwXxo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}