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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e81406348b54dd09e2f3dba6d60cf42c4f13390345b859a969321926cbdb05b5' 
  AND token = '22SqQvII1u0Mb0tWA866tx3s7S9NYMZqg5QfOql4Ruc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}