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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '36649bb2fd443c6f1e1089771d6986d9412a16915a55b9f19c3a7c568c8a3351' 
  AND token = 'LuaBuPIKKYkmAMGPwILwnE48WLcMPCvG9Np6sqeBnvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}