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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80bd297b9f3f4a9478de157f57c0f2b25a04026ffc376b7d727222b4df8a745c' 
  AND token = 'Ey2rW3T59R+qQNu1Pulp2kcR0X6lPA/TP26w1nZbgls=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}