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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '748d6541c19bae8bcbade0ec5679915e10bc618da6f8a156aa6f5b5057c7c75a' 
  AND token = 'q1YZZILFR+8xW5KS4J4adonLVp8dPkTltRiDslPd0WY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}