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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b43ba309369f93a4c0bb2c201cfc80d1d0b834241ec538bf06c48112420795e' 
  AND token = 'e4HCEYlgqEGuoZ1pqgkiUzO/guPIqN/PWrj3dzjX5Ws=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}