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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1374e7f03119c187e3cbfe04deda121ac422ec9009755eb9a8c45239457c9b2a' 
  AND token = '5UVkl7VY1eWAzx/XvaxJL9CowMAh0BhRSSUDStSMH6s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}