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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '169b9eb84cfee054a509b6cd82819f402d54c1446ca741392eeed92472560ef4' 
  AND token = 'VGtIx2iAd9d/xH+GcWeOZiiuoME0csecxFRF+9TGJAc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}