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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6737a2340ddd4650d09e6217bd054d07cac86ae3e2505704a5af05ed48e79ab3' 
  AND token = 'R7Wxw7TtA/O71XLEbS6/3mDvqZtR+nbsZbsY1EPrTlg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}