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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '99e104431bbf09a250a6911eaf1f292e468e13c45d07f9b6619e21d55d119d93' 
  AND token = 'HBxF0vy4OsgcGWt2znU+6LyPmWiAejnh5Ak/XvDvouc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}