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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33e1fcac1da449444c07eb7f8fbf695ee9ec26e8fee93090417d3d44668fdb78' 
  AND token = 'vHkWGCEqpyg/rIiWNN6tPo1UTH35NhbUNIxZlwAqz4E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}