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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a895e77c0fcafa1962cd7611f0eb42b0d2f6f31f8f9dec4f4affb63cebac159' 
  AND token = 'gCLZwUCNJXj0kaLVAgb9UVwhhwzAWR7gsSEiub2Zweg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}