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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e46c10e5fb297502e4b007b21af46b0208a0e3836ad8c17e5d6299bf0cb10a1' 
  AND token = '4lEQaQpF67xGGTJ8WpDqHrKgZgXtZQWMVGcmw0QpS/0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}