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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2568a60db883edb47ceb20e0a018a2064e41fdeeff73e1f389548ac586a44e31' 
  AND token = 'fVO0QhGmAk62Ie+XkJhEkBV8qZiZBNAl0wQNVAXtIVw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}