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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ef49ff4f6889c10667e73298a0c553ef0b688a791f6d157003f6d4228b6de2a' 
  AND token = 'Bs37Gk7jarU7p2PmLkiBBPMmUedVKFjRJaJa1Y75+hE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}