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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14ed165a22d9ebdbfde28dda2a51b849b7b7e423d0230636a268c2a6b3e0f016' 
  AND token = 'SR0L5FiaeNPBNAEvOnLwO0gRzIFxLlBQkmQFqzWhBFs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}