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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c6a1743e37628f7605aed258c7bb639fe14e984270a436ad04e21a3ad3b1af7' 
  AND token = 'RMumoA+WRsD8qrofwGDZgW9WvSek0JobWveqnUwEzIM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}