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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '454ab2b2a79e68e4bb940ecb846c325c57a87db05eb0d9ffe7c3e981eadc6bc2' 
  AND token = 'qoEuFvzCo+wt3qQm4Fr1mmnXnCkiWRO/DEWZx1N7G90=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}