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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9b9270eb108e9b1eace0aee3f3a05148d5f756a0158aefc45aacf794a0e2d537' 
  AND token = 'ZvA1io7Yg6j2zN2MxHZ+hSVKv6kUHDG2jfiuwj+TG60=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}