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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01f1d4bf8ba076f6f39bd1ecacfc435824a53a72fb2cfe5e72c5a1e801747b73' 
  AND token = 'nU1TYSbUG+Hr4YhQVWyUzqc78kxK4m2zXRcVsyZxoPA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}