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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a48a12a7a100084c9207529a2e538fddc138eb6689903379689cf5261ed1daa' 
  AND token = 'iV+mTXWmbp3hzo/9pxWl2Q8BJGLW8F9yJjadkp9jepI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}