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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cdb1be0c8e5bb3f6b07c66062a280578cd56316cd9e735f0d6af92ced4d37b28' 
  AND token = '2Ww9qtrG8O/fcysk6mrFQ/Red/WW3Th2cMg+KaGWKyM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}