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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75c639d8dfd266aaaff028efa0c82d9eb5578d224c04bef8aeea48f5f4d192b6' 
  AND token = '/78Wr7Rwp9aFD/MkpSObe5578x6oHmFF1plYFDw5gic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}