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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22625f77b60ce5ce101c8a16babba3d97af64c7f7de5ce03bac93f977feb69d3' 
  AND token = 'PXkZFGkP/z6HXt0xea+P/LZA2DtG4LNiTfpkPvmE1Rs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}