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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed438c7a2a7eed0d209d2321007e0e68d2e6cdf56810fd592d56c04c476d100c' 
  AND token = 'YmuM8o/fOYL4pyeWtv92YT8E1FLEmt7MZmWjVALPM/Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}