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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b918f51dc76601d2556ace752b2f1343994ea985d568f41e3364c7eb30f6140' 
  AND token = '2ga4cDMtoGOPoDYdgSlv+MFj1A7s4bXnS+CUOn0xS4c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}