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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d2e1755e5a1c60d9d82c58cf4863e6a72f85525366426b20c9332aa82522d82' 
  AND token = 'Otree0am1fkPF9uqkuazsqmyT0G1T2dUj2TLqgemMJk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}