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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ef19ab53cf332e8adaa842ce956a09b84fd67e9628c2e49a1fe2fe379957071' 
  AND token = 'k90v8mWbV2Ukayrq7cTlB8IUdNzkSf0EI4Yo6Vqfx74=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}