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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14501021c4452c365cd6df96dccf62bff4caa7a2fd2bdddaa2c146abff921df2' 
  AND token = '1iRUwDd2iUkxpZYhkke8mRM0ykQwmgOi4pxOPjgQSnE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}