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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5863ff4bd2960f5e09777e1cceebeb72bb25f7e6e9f8af9e0b755e9439927939' 
  AND token = 'l3eREzzmqh8DkWnH/XDCcbedE1rarozF+hjtAouZylk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}