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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d821f4c191190099fbc7e816bd721e2edb41e9a7bb3f18c9f2b8a24b50bd5fb' 
  AND token = 'u9Venf77lJYmzJdZ3VVNqtO27YD3P1GvJ4ZicrwWY7c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}