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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37333230a71df7faabf42a58f6a5bd1875b34fb1f4b2b839ba8169a9ed6c1efc' 
  AND token = 'xWZTw2+582t1YWNWdW9HQraSRFE6oL9DaUP74dm/RuI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}