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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '331498b3bd0f2e28e0c5e49d64f74fbd889537353cf7d7584af482fb2cb61c44' 
  AND token = 'xGE+n368DamDVM8rMSADgwBGLXLgzI0f6LBVAmVXJxo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}