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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '88e16de03c9a4485d8b155b7af1949adbc178af13a21d6ff11793ec3b2c5dd49' 
  AND token = 'X2MvkGZm0IVOZjAnUTU07gH0fjW9xZrdY5VjyyVcbxk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}