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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '388c7c86b8bcf54810d0a91e96cde9b81bd621f763381846579af0250239e4c4' 
  AND token = 'So50JnMzJKcWU661RCCUjORA7yBtuLm2CnfLz5zilVc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}