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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43fbcb47fafb8b6ede82c78ccc198db2bd25183ccb0a02b7818177a0783ee96d' 
  AND token = 'J4HqJlGupGVjLwTZc4yu+z7OGSFJ5KyVNbdNN9V31Zs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}