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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '63d62c62cac110112ee88cdfa69470b50215740a0b65d959c2b6d1649e80c9bd' 
  AND token = 'VQXZk5WKjLeugqw0f+PEgPHR6aKMLIsSTlpeatjr2Gc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}