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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52a117bb389e7eb937c91abbeb74cc8402c6fbb10947602e4165fa8cf653ca41' 
  AND token = 'nSUkayOtTA6b5bD4YSVOHnjKSZmhCg2Ph5aBGAMTEXc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}