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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4c135694e831b13eb81b5ee0145242e5794b6867eb9d0a5fe229a39c820e521' 
  AND token = 'isDRW+ALcFZDOOkb4E45XrFSlp5fQUDndO3efzs4zBs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}