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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c7121b99a11b4238aeb85013f06b40e688af33521daddd3e9a74c1b26b8b688' 
  AND token = '5p090RFU85BgLlsROWkMAm6hltG7pMtJ9kPwRrm2cTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}