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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2215b48294b8e053fd4e7136a1c71c259259d6df046dc0612d1d73e0977a5b80' 
  AND token = 'pDmdIp9IBotj8qw2TP7/zkE2UCkD64qPqsg22oN9HUI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}