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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c485ab5ddce50d5d81f29aafefafd7f1b8b684bf58df77a4d229de43a002011' 
  AND token = 'UhunZDK0dBep5K7A/QbEQ92IFdhLWBk6wj7QBUHj6V0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}