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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21d727d24e3263e051383cd0f3fc627f2100615ea51e397d5ea6166bff746866' 
  AND token = 'zYQex0FHs9lqlTRF8m6qp4x7g83xvqPIBap2mcdOdfg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}